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Home >> Antibodies >> CD11b Antibody / MAC-1 / ITGAM

CD11b Antibody / MAC-1 / ITGAM (F40833)

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  Catalog No Formulation Size Price (USD)  
Image F40833-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 439
Image
F40833-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 205
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Western blot testing of human spleen lysate with CD11b antibody. Expected molecular weight: 128-170 kDa depending on glycosylation level.
IHC testing of FFPE human tonsil with CD11b antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
IHC testing of FFPE human speen with CD11b antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
CD11b antibody flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary Ab was used for the analysis.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Host Rabbit
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P11215
Localization Cell membrane, cytoplasm
Applications IHC (Paraffin) : 1:50-1:100
Flow Cytometry : 1:10-1:50
Western Blot : 1:1000
Limitations This CD11b antibody is available for research use only.
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Description

CD11b is the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.

See our CD11b Antibody ITGAM/3338 page for a monoclonal antibody targeting the ITGAM alpha chain.

Application Notes

Titration of the CD11b antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 253-282 from the human protein was used as the immunogen for this CD11b antibody.

Storage

Aliquot the CD11b antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Alternate Names

Granulocyte marker

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