CD107a Antibody LAMP1/7457 | V4332 NSJ Bioreagents

	Catalog No	Formulation	Size	Price (USD)
	V4332-100UG	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide	100 ug	559
Formulation
	V4332-20UG	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide	20 ug	259
Formulation
	V4332SAF-100UG	1 mg/ml in 1X PBS; BSA free, sodium azide free	100 ug	559
Formulation

CD107a Antibody Human Prostate IHC. Immunohistochemical staining of FFPE human prostate tissue using CD107a antibody (clone LAMP1/7457) following heat-induced epitope retrieval in pH9 Tris-EDTA buffer. Staining was visualized using an HRP secondary antibody with DAB chromogen. Membranous and cytoplasmic staining is observed in the prostate epithelium, consistent with the lysosomal localization of CD107a (Lysosomal Associated Membrane Protein 1). This result demonstrates that the CD107a antibody is suitable for detecting endogenous LAMP1 expression in FFPE human prostate tissue.

CD107a Antibody Human Tonsil IHC. Immunohistochemical staining of FFPE human tonsil tissue using CD107a antibody (clone LAMP1/7457) following heat-induced epitope retrieval in pH9 Tris-EDTA buffer. Staining was visualized using an HRP secondary antibody with DAB chromogen. Distinct membranous and cytoplasmic staining is observed in scattered immune cells within the tonsil, consistent with the expression pattern of CD107a (Lysosomal Associated Membrane Protein 1) in activated lymphocytes and other immune cell populations. This result demonstrates that the CD107a antibody is suitable for detecting endogenous LAMP1 expression in FFPE human lymphoid tissue.

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CD107a Antibody Human Prostate IHC. Immunohistochemical staining of FFPE human prostate tissue using CD107a antibody (clone LAMP1/7457) following heat-induced epitope retrieval in pH9 Tris-EDTA buffer. Staining was visualized using an HRP secondary antibody with DAB chromogen. Membranous and cytoplasmic staining is observed in the prostate epithelium, consistent with the lysosomal localization of CD107a (Lysosomal Associated Membrane Protein 1). This result demonstrates that the CD107a antibody is suitable for detecting endogenous LAMP1 expression in FFPE human prostate tissue.

CD107a Antibody Human Tonsil IHC. Immunohistochemical staining of FFPE human tonsil tissue using CD107a antibody (clone LAMP1/7457) following heat-induced epitope retrieval in pH9 Tris-EDTA buffer. Staining was visualized using an HRP secondary antibody with DAB chromogen. Distinct membranous and cytoplasmic staining is observed in scattered immune cells within the tonsil, consistent with the expression pattern of CD107a (Lysosomal Associated Membrane Protein 1) in activated lymphocytes and other immune cell populations. This result demonstrates that the CD107a antibody is suitable for detecting endogenous LAMP1 expression in FFPE human lymphoid tissue.

Availability	1-3 business days
Species Reactivity	Human
Format	Purified
Host	Mouse
Clonality	Monoclonal (mouse origin)
Isotype	Mouse IgG1, kappa
Clone Name	LAMP1/7457
Purity	Protein A/G affinity
UniProt	P11279
Localization	Cytoplasm, Cell membrane
Applications	Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations	This CD107a antibody is available for research use only.
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Description

CD107a Antibody / Lysosomal Associated Membrane Protein 1 Antibody recognizes CD107a, the cluster of differentiation designation for Lysosomal Associated Membrane Protein 1 (LAMP1), a highly glycosylated transmembrane protein that is abundantly expressed on lysosomal membranes. Under resting conditions, CD107a is localized primarily within lysosomes and late endosomes, but during lysosomal exocytosis it is transiently displayed on the cell surface. This dynamic trafficking has made CD107a one of the most widely used markers for monitoring immune cell activation and degranulation. A CD107a Antibody is valuable for investigating both lysosomal biology and cytotoxic immune responses.

Surface expression of Lysosomal Associated Membrane Protein 1 is routinely measured as an indicator of degranulation by natural killer cells and cytotoxic T lymphocytes. During target-cell killing, secretory lysosomes fuse with the plasma membrane to release perforin and granzymes while simultaneously exposing CD107a on the cell surface. Because this response closely reflects cytotoxic activity, CD107a has become a standard functional marker in cancer immunology, infectious disease, vaccine development, transplantation, and cellular immunotherapy. Beyond immune activation, Lysosomal Associated Membrane Protein 1 also contributes to lysosome stability, intracellular trafficking, and autophagy.

Abnormal CD107a expression or lysosomal trafficking has been linked to immune dysfunction, lysosomal storage disorders, neurodegenerative disease, chronic inflammation, infection, and cancer. CD107a antibodies are widely used for flow cytometry as well as immunohistochemistry, immunofluorescence, Western blotting, and related protein detection methods when validated for the specific application. NSJ Bioreagents provides carefully validated antibodies to support investigations of immune cell activation, lysosomal trafficking, autophagy, and cancer immunology. A CD107a Antibody / Lysosomal Associated Membrane Protein 1 Antibody is a valuable research reagent for detecting CD107a and advancing studies of cytotoxic lymphocyte degranulation, lysosomal membrane dynamics, and immune-mediated disease.

Visit our LAMP1 Antibody / Lysosomal Membrane Glycoprotein Antibody page to explore additional validated antibodies and research tools for investigating LAMP1 expression, lysosomal membrane biology, intracellular trafficking, autophagy, and immune cell function.

Application Notes

Optimal dilution of the CD107a Antibody / Lysosomal Associated Membrane Protein 1 Antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the CD107a antibody.

Storage

Aliquot the CD107a antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Alternate Names

CD107a antibody, Lysosomal Associated Membrane Protein 1 antibody, LAMP1 antibody, Lysosomal Membrane Glycoprotein antibody, Lysosome Associated Membrane Glycoprotein 1 antibody, Lysosome Marker antibody

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CD107a Antibody / Lysosomal Associated Membrane Protein 1 Antibody [clone LAMP1/7457] (V4332)

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