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Home >> Antibodies >> CD105 Antibody / Endoglin

CD105 Antibody / Endoglin [clone ENG/1326] (V3340)

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  Catalog No Formulation Size Price (USD)  
Image V3340-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3340-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3340SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Western blot testing of human 1) HeLa, 2) A431 and 3) HL60 cell lysate with CD105 antibody (clone ENG/1326). Observed molecular weight: 70/90 kDa (monomer, unmodified/glycosylated); 140-180 kDa (dimer, unmodified/glycosylated).
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Western blot testing of human 1) HeLa, 2) A431 and 3) HL60 cell lysate with CD105 antibody (clone ENG/1326). Observed molecular weight: 70/90 kDa (monomer, unmodified/glycosylated); 140-180 kDa (dimer, unmodified/glycosylated).
SDS-PAGE Analysis of Purified, BSA-Free CD105 Antibody (clone ENG/1326). Confirmation of Integrity and Purity of the Antibody.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name ENG/1326
Purity Protein G affinity chromatography
UniProt P17813
Localization Cell surface, cytoplasmic
Applications Western blot : 1-2ug/ml
Limitations This CD105 antibody is available for research use only.
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Description

CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. CD105 has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. It is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.

Application Notes

Titering of the CD105 antibody may be required for optimal performance.

Immunogen

A partial recombinant protein corresponding to amino acids 74-251 of human CD105/Endoglin was used as the immunogen for the CD105 antibody.

Storage

Store the CD105 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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