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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Endoglin (ENG), also known as CD105, is a transmembrane glycoprotein predominantly expressed on vascular endothelial cells, where it functions as an important regulator of angiogenesis and vascular remodeling. CD105 Antibody / Endoglin Endothelial Marker Antibody targets this protein, which is primarily localized to the cell membrane with additional cytoplasmic distribution reflecting receptor synthesis and trafficking. CD105 antibody, also referred to as Endoglin antibody and ENG antibody in the literature, detects a key endothelial marker widely used in studies of vascular biology and tumor-associated angiogenesis.
Functionally, Endoglin plays a central role in transforming growth factor beta (TGF-beta) signaling pathways, modulating endothelial cell proliferation, migration, and survival. It acts as a co-receptor for TGF-beta ligands and contributes to the regulation of vascular development and repair. CD105 expression is strongly associated with active angiogenesis, particularly in tumor tissues, where proliferating endothelial cells exhibit elevated levels of Endoglin compared to normal vasculature. This makes CD105 a widely used marker for identifying neovascularization and assessing tumor vascular density.
CD105 is highly expressed in endothelial cells lining blood vessels across a wide range of tissues, including kidney, liver, and spleen, and is particularly enriched in newly formed or remodeling vessels. In tumor tissues, CD105-positive endothelial cells are commonly observed within the tumor microenvironment, reflecting ongoing angiogenic activity. Expression may also be detected in certain stromal and progenitor cell populations involved in vascular development. The ENG gene is located on chromosome 9q34.11 and is associated with hereditary hemorrhagic telangiectasia when mutated, highlighting its critical role in vascular integrity.
Structurally, Endoglin is a homodimeric membrane protein consisting of a large extracellular domain, a single transmembrane region, and a short cytoplasmic tail that participates in intracellular signaling. It interacts with components of the TGF-beta receptor complex and modulates downstream signaling cascades that influence endothelial cell behavior. Endoglin may also co-localize with other vascular markers and signaling molecules involved in angiogenesis and vascular homeostasis.
Altered CD105 expression is closely associated with pathological conditions involving abnormal angiogenesis, including cancer, cardiovascular disease, and inflammatory disorders. In oncology, increased Endoglin expression correlates with tumor progression and metastasis, reflecting enhanced vascularization. In inflammatory settings, CD105-positive endothelial cells contribute to tissue repair and immune cell trafficking.
This antibody provides reliable detection of CD105 / Endoglin across multiple experimental approaches, supporting its use as an endothelial marker in immunohistochemistry, immunofluorescence, western blot, and flow cytometry applications. A CD105 antibody is suitable for detecting this angiogenesis-associated protein in studies of vascular biology, tumor progression, and endothelial cell function.
This CD105 antibody is part of a broader CD antibody panel offered by NSJ Bioreagents.
Optimal dilution of the CD105 Antibody / Endoglin Endothelial Marker Antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids E26-H267) was used as the immunogen for the CD105 antibody.
After reconstitution, the CD105 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Endoglin antibody, ENG antibody, CD105 endothelial antibody, Endoglin angiogenesis antibody, ENG vascular marker antibody
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