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Home >> Antibodies >> CCR5 Antibody

CCR5 Antibody (R32995)

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  Catalog No Formulation Size Price (USD)  
Image R32995 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) Jurkat and 2) MCF7 cell lysate with CCR5 antibody at 0.5ug/ml. Predicted molecular weight ~41 kDa.
Western blot testing of human 1) Jurkat and 2) MCF7 cell lysate with CCR5 antibody at 0.5ug/ml. Predicted molecular weight ~41 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt P51681
Applications Western Blot : 0.5-1ug/ml
Limitations This CCR5 antibody is available for research use only.
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Description

Human CC chemokine receptor 5 (CCR5), which is 17.5 kb from the CMKBR2 gene, encodes a 352-amino acid protein with a calculated molecular mass of 40,600 Da. It is organized into four exons and two introns. Human CCR5 is a co-receptor for macrophage-tropic strains of human immunodeficiency virus (HIV)-1 and is expressed by bone-marrow-derived cells. CCR5 is expressed on neurons, astrocytes, and microglia in the central nervous system, and on epithelium, endothelium, vascular smooth muscle and fibroblasts in other tissues. Functionally, CCR5 mediates the activation of cells by the chemokines macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES, and serves as a fusion cofactor for macrophage-tropic strains of human immunodeficiency virus type 1.

Application Notes

Optimal dilution of the CCR5 antibody should be determined by the researcher.

Immunogen

Amino acids YSGILKTLLRCRNEKKRHRAVRLIFT from the human protein were used as the immunogen for the CCR5 antibody.

Storage

After reconstitution, the CCR5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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