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Home >> Antibodies >> CCR5 Antibody

CCR5 Antibody (R30187)

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  Catalog No Formulation Size Price (USD)  
Image R30187 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of CCR5 antibody and Lane 1: COLO320; 2: MCF-7; 3: SMMC-7721; 4: Jurkat cell lysate. Predicted molecular weight ~41 kDa.
Western blot testing of CCR5 antibody and Lane 1: COLO320; 2: MCF-7; 3: SMMC-7721; 4: Jurkat cell lysate. Predicted molecular weight ~41 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P51681
Applications Western blot : 0.5-1ug/ml
Limitations This CCR5 antibody is available for research use only.
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Description

Human CC chemokine receptor 5(CCR5), which is 17.5 kb from the CMKBR2 gene, encodes a 352-amino acid protein with a calculated molecular mass of 40,600 Da. It is organized into four exons and two introns. Human CCR5 is a co-receptor for macrophage-tropic strains of human immunodeficiency virus(HIV)-1 and is expressed by bone-marrow-derived cells. CCR5 is expressed on neurons, astrocytes, and microglia in the central nervous system, and on epithelium, endothelium, vascular smooth muscle and fibroblasts in other tissues. Functionally, CCR5 mediates the activation of cells by the chemokines macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES, and serves as a fusion cofactor for macrophage-tropic strains of human immunodeficiency virus type 1.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the CCR5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the middle region of human CCR5 (SSHFPYSQYQFWKNFQTLK) was used as the immunogen for this CCR5 antibody.

Storage

After reconstitution, the CCR5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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