- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CCR1 Antibody / C-C chemokine receptor type 1 (FY13339)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13339 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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CCR1 antibody detects C-C chemokine receptor type 1, a G proteincoupled receptor (GPCR) encoded by the CCR1 gene on chromosome 3p21.31. CCR1 is a membrane receptor primarily expressed on monocytes, macrophages, neutrophils, and T lymphocytes, where it mediates chemotactic responses to inflammatory chemokines. As part of the beta chemokine receptor family, CCR1 plays a central role in immune cell trafficking, inflammation, and host defense. High expression levels are observed in bone marrow, spleen, and peripheral blood leukocytes, highlighting its function in immune surveillance and leukocyte migration.
CCR1 binds multiple chemokines, including CCL3 (MIP-1alpha), CCL5 (RANTES), and CCL7 (MCP-3), triggering intracellular signaling cascades that guide immune cells toward infection or inflammation sites. Ligand binding activates G proteinmediated signaling through phospholipase C, PI3K, and MAPK pathways, resulting in cytoskeletal rearrangement, integrin activation, and chemotaxis. CCR1 also contributes to immune homeostasis by regulating leukocyte retention and activation in tissue microenvironments.
Structurally, CCR1 consists of seven transmembrane alpha-helices characteristic of GPCRs, with extracellular loops for ligand recognition and an intracellular C-terminal tail that interacts with G proteins and regulatory kinases. CCR1 belongs to the C-C chemokine receptor family, which includes CCR2CCR5, all mediating overlapping but distinct immune signaling profiles. Co-localization studies show CCR1 residing in lipid rafts and endocytic vesicles, allowing rapid receptor internalization and recycling after ligand stimulation.
Functionally, CCR1 regulates leukocyte trafficking during inflammation, autoimmune response, and hematopoiesis. It is critical for monocyte and neutrophil recruitment to sites of infection and tissue injury. The receptor also participates in bone remodeling by influencing osteoclast differentiation through CCL5 signaling. In the nervous system, CCR1 modulates neuroinflammation by controlling microglial migration and cytokine release.
Dysregulation of CCR1 contributes to various pathological conditions including rheumatoid arthritis, multiple sclerosis, and chronic obstructive pulmonary disease (COPD). Overexpression enhances leukocyte infiltration and tissue inflammation, whereas pharmacological inhibition of CCR1 has shown therapeutic potential in autoimmune and fibrotic disorders. Pathway involvement includes chemokine-mediated signaling, GPCR activation, and NF-kappaB inflammatory pathways. During development, CCR1 expression is upregulated in hematopoietic progenitors and inflammatory cells responding to infection.
Immunohistochemical staining using CCR1 antibody demonstrates plasma membrane localization in leukocytes and macrophages. The CCR1 antibody from NSJ Bioreagents is ideal for studies of chemokine receptor biology, leukocyte trafficking, and inflammatory disease mechanisms.
Optimal dilution of the CCR1 antibody should be determined by the researcher.
A synthetic peptide corresponding to a sequence at the C-terminus of mouse CCR1 was used as the immunogen for the CCR1 antibody.
After reconstitution, the CCR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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