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Home >> Antibodies >> CCND1 Antibody

CCND1 Antibody (F52187)

  Catalog No Formulation Size Price (USD)  
Image F52187-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 379
Image
F52187-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 155
CCND1 antibody western blot analysis in (1) human A431, (2) mouse L929 and (3) rat C6 lysate. Predicted molecular weight: 32-36 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Predicted Reactivity Bovine
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P24385
Applications Western blot : 1:1000
Limitations This CCND1 antibody is available for research use only.
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Description

Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Application Notes

Titration of the CCND1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 264-292 from the human protein was used as the immunogen for this CCND1 antibody.

Storage

Aliquot the CCND1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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