- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Caudal type homeobox transcription factor 2 Antibody / CDX2 [clone CDX2/9338] (V5646)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5646-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 539 | |
|
|
V5646-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 249 | |
|
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V5646SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | CDX2/9338 |
| Purity | Protein G affinity |
| UniProt | Q99626 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Caudal type homeobox transcription factor 2 antibody is available for research use only. |
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Caudal type homeobox transcription factor 2 antibody detects CDX2, a nuclear transcription factor encoded by the CDX2 gene. CDX2 plays a central role in intestinal development and epithelial differentiation, where it directs expression of genes required for cell polarity, adhesion, and digestive function. Because CDX2 is strongly expressed in gastrointestinal epithelium and associated tumors, Caudal type homeobox transcription factor 2 antibody has become an essential marker in pathology, developmental biology, and oncology.
CDX2 belongs to the caudal-related homeobox family of transcription factors, containing a highly conserved DNA-binding homeodomain. By binding to cis-regulatory regions, CDX2 activates genes that promote intestinal identity, villus formation, and epithelial maintenance. Its expression is tightly regulated during embryogenesis, appearing early in posterior gut development. In adults, CDX2 continues to maintain intestinal epithelial function, highlighting its lifelong significance.
The Caudal type homeobox transcription factor 2 antibody clone CDX2/9338 provides reliable and specific detection. Clone CDX2/9338 has been cited in peer-reviewed publications addressing gastrointestinal tumor classification and developmental regulation of the intestine. Its reproducibility makes it a valuable reagent for diagnostic and research purposes. In pathology, CDX2 detection helps determine the origin of metastatic adenocarcinomas, where intestinal tumors show strong nuclear positivity while other carcinomas do not.
Research using clone CDX2/9338 has shown that loss of CDX2 expression in colorectal cancer correlates with poor prognosis and aggressive features. Beyond oncology, studies have used this antibody to explore transcriptional networks governing intestinal differentiation and epithelial plasticity. Because CDX2 functions as both a lineage marker and a regulator of cell identity, its detection informs research in normal development, disease, and regenerative medicine.
NSJ Bioreagents provides this Caudal type homeobox transcription factor 2 antibody to support oncology, pathology, and developmental biology. Alternate names include CDX2 antibody, caudal related homeobox protein 2 antibody, intestinal transcription factor antibody, homeobox protein CDX2 antibody, and gastrointestinal lineage marker antibody.
Optimal dilution of the Caudal type homeobox transcription factor 2 antibody should be determined by the researcher.
A portion of amino acids 150-249 from human CDX2 protein was used as the immunogen for the Caudal type homeobox transcription factor 2 antibody.
Aliquot the Caudal type homeobox transcription factor 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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