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Home >> Antibodies >> Cathepsin K Antibody

Cathepsin K Antibody [clone CTSK/2793] (V7707)

  Catalog No Formulation Size Price (USD)  
Image V7707-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7707-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V7707SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated
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IHC staining of FFPE human hepatocellular carcinoma with Cathepsin K antibody (clone CTSK/2793). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.
IHC staining of FFPE human liver with Cathepsin K antibody (clone CTSK/2793). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Cathepsin K antibody (clone CTSK/2793). These results demonstrate the foremost specificity of the CTSK/2793 mAb.
Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
SDS-PAGE analysis of purified, BSA-free Cathepsin K antibody (clone CTSK/2793) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name CTSK/2793
Purity Protein G affinity chromatography
UniProt P43235
Localization Cytoplasmic
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This Cathepsin K antibody is available for research use only.
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Description

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

Application Notes

Optimal dilution of the Cathepsin K antibody should be determined by the researcher.

Immunogen

A recombinant human partial protein (amino acids 163-274) was used as the immunogen for the Cathepsin K antibody.

Storage

Store the Cathepsin K antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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