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Home >> Antibodies >> Cathepsin D Antibody / CTSD

Cathepsin D Antibody / CTSD (R31479)

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  Catalog No Formulation Size Price (USD)  
Image R31479 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of Cathepsin D antibody and mouse samples: 1: liver; 2: brain; 3: thymus; 4: Neuro-2a lysate. Expected molecular weight: 43-46 kDa, 28 kDa (heavy chain), 15 kDa (light chain).
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Western blot testing of Cathepsin D antibody and mouse samples: 1: liver; 2: brain; 3: thymus; 4: Neuro-2a lysate. Expected molecular weight: 43-46 kDa, 28 kDa (heavy chain), 15 kDa (light chain).
IHC-P: Cathepsin D antibody testing of mouse kidney tissue
IHC-P: Cathepsin D antibody testing of mouse liver tissue
IHC-P: Cathepsin D antibody testing of rat liver tissue. HIER: steam section in pH6 citrate buffer for 20 min.
Availability 1-3 business days
Species Reactivity Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Gene ID 13033
Localization Cytoplasmic
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This Cathepsin D antibody is available for research use only.
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Description

Cathepsin D is a protein that in humans is encoded by the CTSD gene. This proteinase is a member of the peptidase C1 family, having a specificity similar to but narrower than that of pepsin A. It is mapped to 11p15.5. The cDNA encodes a 412-amino acid protein with 20 and 44 amino acids in a pre- and prosegment, respectively. Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease and it has been considered as a breast cancer tumor marker.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the Cathepsin D antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Mouse partial recombinant protein (AA 65-410) was used as the immunogen for this Cathepsin D antibody.

Storage

After reconstitution, the Cathepsin D antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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