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Home >> Antibodies >> Cathepsin D Antibody / CTSD

Cathepsin D Antibody / CTSD [clone CTPD-1] (V7644)

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  Catalog No Formulation Size Price (USD)  
Image V7644-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 559
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V7644-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 259
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V7644SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
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IHC staining of FFPE human liver tissue with Cathepsin D antibody (clone CTPD-1). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.
Western blot testing of human liver lysate with CTSD antibody (clone CTPD-1).
Species Reactivity Human
Format Purified
Host Mouse
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name CTPD-1
Purity Protein G affinity chromatography
UniProt P07339
Localization Cytoplasmic
Applications Immunohistochemistry (FFPE) : 0.5-1ug/ml
Western Blot : 1-2ug/ml
Limitations This Cathepsin D antibody is available for research use only.
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Description

Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52kDa preprocathepsin D that is cleaved and glycosylated to form a 48kDa procathepsin D and then further cleaved to produce 34kDa and 14kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

This antibody can be compared with our Cathepsin D Antibody / CTSD Antibody (clone CTSD/3276) as a central reference for consistent CTSD detection across multiple assay formats.

Application Notes

Optimal dilution of the CTSD antibody should be determined by the researcher.

Immunogen

Amino acids 104-250 were used as the immunogen of the Cathepsin D antibody.

Storage

Store the Cathepsin D antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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   1.   View all CTSD antibodies

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