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Home >> Antibodies >> Cathepsin D Antibody / CTSD

Cathepsin D Antibody / CTSD [clone CTPD-1] (V7644)

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  Catalog No Formulation Size Price (USD)  
Image V7644-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7644-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V7644SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human liver tissue with Cathepsin D antibody (clone CTPD-1). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.
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IHC staining of FFPE human liver tissue with Cathepsin D antibody (clone CTPD-1). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.
Western blot testing of human liver lysate with CTSD antibody (clone CTPD-1).
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name CTPD-1
Purity Protein G affinity chromatography
UniProt P07339
Localization Cytoplasmic
Applications Immunohistochemistry (FFPE) : 0.5-1ug/ml
Western blot : 1-2ug/ml
Limitations This Cathepsin D antibody is available for research use only.
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Description

Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52kDa preprocathepsin D that is cleaved and glycosylated to form a 48kDa procathepsin D and then further cleaved to produce 34kDa and 14kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Application Notes

Optimal dilution of the CTSD antibody should be determined by the researcher.

Immunogen

Amino acids 104-250 were used as the immunogen of the Cathepsin D antibody.

Storage

Store the Cathepsin D antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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