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Home >> Antibodies >> Caspase-3 Antibody

Caspase-3 Antibody [clone 1262CT521.280.101] (F52416)

  Catalog No Formulation Size Price (USD)  
Image F52416-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 389
Image
F52416-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 155
Caspase-3 antibody western blot analysis in Jurkat, Ramos lysate
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1
Clone Name 1262CT521.280.101
Purity Purified
UniProt P42574
Applications Western blot : 1:2000
Limitations This Caspase-3 antibody is available for research use only.
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Description

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Application Notes

Titration of the Caspase-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Purified His-tagged protein was used to produced this monoclonal Caspase-3 antibody.

Storage

Aliquot the Caspase-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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