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Home >> Antibodies >> Carboxypeptidase A1 Antibody / CPA1

Carboxypeptidase A1 Antibody / CPA1 [clone CPA1/8777] (V5486)

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  Catalog No Formulation Size Price (USD)  
Image V5486-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 539
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V5486-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 249
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V5486SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 539
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IHC staining of FFPE human pancreas tissue with Carboxypeptidase A1 antibody (clone CPA1/8777). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human pancreas tissue with Carboxypeptidase A1 antibody (clone CPA1/8777). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Carboxypeptidase A1 antibody (clone CPA1/8777) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name CPA1/8777
Purity Protein A/G affinity
UniProt P15085
Localization Secreted
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This Carboxypeptidase A1 antibody is available for research use only.
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Description

Human pancreatic procarboxypeptidase A exists as three different active forms, two of which are designated carboxypeptidase A1 (CPA1) and carboxypeptidase A2 (CPA2). CPA1, also known as CPA, is a 419 amino acid secreted monomeric protein that is highly expressed in pancreatic tissue. Functioning as a pancreatic exopeptidase, CPA1 uses zinc as a cofactor to catalyze the release of C-terminal amino acids from a variety of proteins, thereby playing a key role in protein digestion and degradation. Via its catalytic activity, CPA1 is also thought to be involved in zymogen (proenzyme) inhibition, probably functioning to block enzyme activation pathways. Abnormal levels of CPA1 are associated with pancreatic cancer, suggesting a possible role in either tumor progression or tumor suppression events.

Application Notes

Optimal dilution of the Carboxypeptidase A1 antibody should be determined by the researcher.

Immunogen

A recombinant fragment (within amino acids 100-300) of human CPA1 protein was used as the immunogen for the Carboxypeptidase A1 antibody.

Storage

Aliquot the Carboxypeptidase A1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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