- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CAR Antibody / Coxsackie Adenovirus Receptor Antibody (R30950)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R30950 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal |
| UniProt | P78310 |
| Applications | Western Blot : 0.5-1ug/ml |
| Limitations | This CAR Antibody / Coxsackie Adenovirus Receptor Antibody is available for research use only. |
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CAR Antibody / Coxsackie Adenovirus Receptor Antibody recognizes CAR, also known as CXADR, a transmembrane cell adhesion protein that belongs to the immunoglobulin superfamily. Although originally identified as the cellular receptor for Coxsackie B viruses and multiple adenovirus serotypes, CAR is now recognized as an important regulator of epithelial integrity, tissue organization, and intercellular communication. The protein is primarily localized at tight junctions and sites of cell-cell contact, where it contributes to adhesion, polarity, and maintenance of epithelial barrier function. A CAR Antibody is widely used to investigate viral entry mechanisms, epithelial biology, cardiovascular development, and cell adhesion.
CAR participates in numerous physiological processes beyond serving as a viral receptor. Through interactions with junctional proteins and intracellular signaling complexes, CAR helps regulate epithelial organization, cellular proliferation, migration, differentiation, and tissue morphogenesis. During embryonic development, CAR is essential for normal heart formation and also contributes to the development of the nervous system, pancreas, and other organs. Because pathogens exploit CAR for host cell attachment and entry, the protein has become an important model for studying virus-host interactions while simultaneously serving as a key marker of epithelial junction biology. A CAR Antibody enables researchers to investigate these diverse biological functions in both normal and pathological settings.
Altered CAR expression has been associated with viral myocarditis, cardiomyopathy, epithelial cancers, pancreatic cancer, colorectal cancer, lung cancer, and neurological disorders. Changes in receptor abundance or localization may influence susceptibility to viral infection, tumor progression, metastatic behavior, epithelial barrier dysfunction, and the efficiency of adenovirus-based gene therapy. Ongoing research continues to explore the relationship between CAR expression and disease progression, making the protein an important biomarker in cardiovascular research, oncology, developmental biology, and virology. Consequently, a CAR Antibody has become a valuable reagent for investigating cell adhesion, viral receptor biology, and tissue homeostasis.
CAR expression is routinely evaluated using Western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, and flow cytometry to examine protein expression, localization, and regulation in cultured cells and tissue samples. Researchers often combine CAR analysis with markers of epithelial junctions, cell adhesion, and viral infection to gain a broader understanding of tissue organization and host-pathogen interactions. NSJ Bioreagents provides carefully validated antibodies to support these research applications. A CAR Antibody / Coxsackie Adenovirus Receptor Antibody is a reliable research tool for investigating epithelial junction biology, viral entry, tissue development, and mechanisms underlying infectious, cardiovascular, and neoplastic diseases.
Visit our CXADR Antibody / Coxsackievirus and Adenovirus Receptor Antibody page to explore additional validated antibodies and research tools for investigating CXADR-mediated cell adhesion, epithelial junction organization, and viral receptor biology.
The stated application concentrations are suggested starting amounts. Titration of the CAR Antibody / Coxsackie Adenovirus Receptor Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the C-terminus of human Coxsackie Adenovirus Receptor (YSKTQYNQVPSEDFER) was used as the immunogen for this CAR antibody (100% homologous in human, mouse and rat).
After reconstitution, the CAR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
CAR antibody, Coxsackie Adenovirus Receptor antibody, CXADR antibody, Coxsackievirus and Adenovirus Receptor antibody
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