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Home >> Antibodies >> CAP1 Antibody / Actin Cytoskeleton Regulator Antibody

CAP1 Antibody / Actin Cytoskeleton Regulator Antibody (R32375)

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Image R32375 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 449
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CAP1 Antibody Human, Rat and Mouse WB. Western blot analysis was performed using CAP1 Antibody. Lane 1: human HeLa whole cell lysate; lane 2: rat thymus tissue lysate; lane 3: rat spleen tissue lysate; lane 4: mouse thymus tissue lysate; lane 5: mouse spleen tissue lysate. Proteins were separated on a 10% SDS-PAGE gel, transferred to a nitrocellulose membrane, and incubated with the primary antibody at 0.5 ug/ml overnight at 4°C. A specific immunoreactive band is detected at approximately 55–60 kDa in all tested samples, consistent with the expected molecular weight of CAP1, which commonly migrates slightly above its predicted size of approximately 52 kDa. These results demonstrate that this Actin Cytoskeleton Regulator Antibody is suitable for Western blot detection of CAP1 across human, rat, and mouse tissues and cell lysates.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Host Rabbit
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q01518
Applications Western Blot : 0.5-1ug/ml
Limitations This CAP1 Antibody / Actin Cytoskeleton Regulator Antibody is available for research use only.
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Description

CAP1 Antibody recognizes Cyclase Associated Protein 1 (CAP1), a highly conserved actin-binding protein that plays a central role in regulating actin filament turnover and cytoskeletal remodeling. Originally identified through its interaction with adenylyl cyclase in yeast, mammalian CAP1 is now known to function primarily as a regulator of actin dynamics by coordinating actin monomer recycling, filament disassembly, and cytoskeletal organization. Through interactions with actin, cofilin, and additional cytoskeletal proteins, CAP1 supports the rapid remodeling of the actin network required for normal cellular architecture and movement. NSJ Bioreagents supplies CAP1 Antibody for reliable detection of this important cytoskeletal regulator in diverse research applications.

CAP1 contributes to numerous cellular processes that depend upon dynamic rearrangement of the actin cytoskeleton, including cell migration, adhesion, cytokinesis, endocytosis, and membrane trafficking. By promoting the exchange of adenosine diphosphate-bound actin monomers for adenosine triphosphate-bound actin and facilitating cofilin-mediated filament turnover, CAP1 helps maintain efficient actin polymerization cycles. These activities enable cells to rapidly alter their morphology in response to developmental, environmental, and signaling cues. Consequently, CAP1 Antibody is widely used to investigate actin dynamics, cytoskeletal organization, and mechanisms governing cell motility.

Altered CAP1 expression has been reported in several human malignancies, including breast, lung, pancreatic, colorectal, and hepatocellular cancers, where dysregulated actin remodeling contributes to tumor cell migration, invasion, and metastasis. Beyond oncology, CAP1 has been implicated in neuronal development, cardiovascular biology, immune cell function, and metabolic regulation, highlighting its broad physiological importance. Because cytoskeletal remodeling underlies many aspects of cell behavior, CAP1 remains an important target for studies of signal transduction, tissue morphogenesis, wound healing, and disease progression.

A CAP1 Antibody is a valuable reagent for investigating actin cytoskeleton regulation, cell migration, membrane dynamics, and cytoskeletal remodeling. By enabling reliable detection of Cyclase Associated Protein 1, a CAP1 Antibody supports research into cell biology, cancer progression, developmental processes, and the molecular mechanisms that control actin-dependent cellular function.

Explore additional antibodies involved in cytoskeletal organization and cellular architecture on our Cell Biology Antibodies page.

Application Notes

Optimal dilution of the CAP1 Antibody / Actin Cytoskeleton Regulator Antibody should be determined by the researcher.

Immunogen

Amino acids A2-R123 of the human protein were used as the immunogen for the CAP1 antibody.

Storage

After reconstitution, the CAP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Alternate Names

Cyclase Associated Protein 1 antibody, CAP antibody, Adenylyl Cyclase Associated Protein 1 antibody, CAP1 Protein antibody, Actin Binding Protein CAP1 antibody, CAP-1 antibody

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