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Home >> Antibodies >> CAMK2A Antibody

CAMK2A Antibody (RQ4384)

  Catalog No Formulation Size Price (USD)  
Image RQ4384 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 449
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CAMK2A Antibody Rat and Mouse Brain WB. Western blot testing of 1) rat brain and 2) mouse brain tissue lysates with CAMK2A antibody at 0.5 ug/ml. Immunoreactive bands are detected at approximately 54 and 60 kDa, consistent with the expected molecular weight of CAMK2A and its phosphorylated or post-translationally modified forms. The results demonstrate specific detection of Calcium/Calmodulin Dependent Protein Kinase II Alpha (CAMK2A), a serine/threonine kinase that regulates synaptic plasticity, learning, memory, and neuronal signal transduction in the central nervous system.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Host Rabbit
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q9UQM7
Localization Cell junction
Applications Western Blot : 0.5-1ug/ml
Direct ELISA : 0.1-0.5ug/ml (human recombinant protein)
Limitations This CAMK2A antibody is available for research use only.
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Description

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298'. Activates FOXO3 transcriptional activity (By similarity). [UniProt]

For additional information on CAMK II alpha biology, calcium-dependent signaling and validated research applications, visit our CAMK II alpha Antibody page.

Application Notes

Optimal dilution of the CAMK2A antibody should be determined by the researcher.

Immunogen

A recombinant human protein corresponding to amino acids L392-R457 was used as the immunogen for the CAMK2A antibody.

Storage

After reconstitution, the CAMK2A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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