Calponin Antibody [clone CLPN5-1] (V7050)

Description

CNN1 is a smooth muscle-specific protein that binds actin filaments and supports regulation of contractile machinery within the cytoskeleton. Calponin is a calmodulin, F-actin and tropomyosin binding protein which is thought to be involved in the regulation of smooth muscle contraction. Calponin expression is restricted to smooth muscle cells and has been shown to be a marker of the differentiated (contractile) phenotype of developing smooth muscle.

This Calponin antibody complements a related Calponin 1 antibody targeting CNN1 and smooth muscle-associated contractile protein biology.

Application Notes

Optimal dilution of the Calponin antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Immunogen

Recombinant human protein was used as the immunogen for the Calponin antibody.

Storage

Store the Calponin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).