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Home >> Antibodies >> Calmodulin Antibody [Discontinued]

Calmodulin Antibody [Discontinued] (R30594)

  Catalog No Formulation Size Price (USD)  
Image R30594 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of Calmodulin antibody and Lane 1: A549; 2: HT1080 cell lysate
IHC-P: Calmodulin antibody testing of human rectal cancer tissue
Availability Discontinued
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P62158
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This Calmodulin antibody is available for research use only.
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Description

Calcium-modulated protein is a calcium-binding protein expressed in all eukaryotic cells. It can bind to and regulate a number of different protein targets, thereby affecting many different cellular functions. Calmodulin mediates processes such as inflammation, metabolism, apoptosis, smooth muscle contraction, intracellular movement, short-term and long-term memory, nerve growth and the immune response. It is expressed in many cell types and can have different subcellular locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes. Many of the proteins that Calmodulin binds are unable to bind calcium themselves, and as such use Calmodulin as a calcium sensor and signal transducer. It can also make use of the calcium stores in the endoplasmic reticulum, and the sarcoplasmic reticulum. The protein undergoes a conformational change upon binding to calcium, which enables it to bind to specific proteins for a specific response. Calmodulin can bind up to four calcium ions, and can undergo post-translational modifications, such as phosphorylation, acetylation, methylation and proteolytic cleavage, each of which has potential to modulate its actions. It can also bind to edema factor toxin from the anthrax bacteria. Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. It contains 149 amino acids and has 4 calcium-binding domains. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters. Three calmodulin genes (CALM1, CALM2, and CALM3) map to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3, respectively.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the Calmodulin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Amino acids 119-136 (DEEVDEMIREADIDGDGQ) were used as the immunogen for this Calmodulin antibody (100% homologous in human, mouse and rat).

Storage

After reconstitution, the Calmodulin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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