- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Calbindin 1 Antibody / CALB1 [clone CALB1/2364] (V8169)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8169-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V8169-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8169SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | CALB1/2364 |
| Purity | Protein G affinity chromatography |
| UniProt | P05937 |
| Localization | Cytoplasmic, nuclear, secreted |
| Applications | ELISA (order BSA-free Format For Coating) : |
| Limitations | This Calbindin 1 antibody is available for research use only. |
|
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Calbindin 1 antibody, also known as CALB1 antibody, recognizes Calbindin 1, a cytoplasmic EF-hand calcium-binding protein commonly referred to as Calbindin-D28k. Encoded by the CALB1 gene on chromosome 8q21, Calbindin 1 is a member of the calbindin subfamily within the larger EF-hand calcium-binding protein family and plays a central role in intracellular calcium buffering. By binding free Ca2+ through multiple EF-hand domains, Calbindin 1 regulates calcium flux, shapes calcium transients, and helps protect cells from calcium-mediated stress. The protein is predominantly localized to the cytoplasm and is highly expressed in defined neuronal populations, including cerebellar Purkinje cells, hippocampal neurons, and subsets of cortical interneurons. Calbindin 1 antibody is therefore widely used as a marker to study neuronal subtype identity and calcium signaling dynamics in both normal and diseased tissue.
Beyond the central nervous system, Calbindin 1 is detected in peripheral tissues such as kidney distal tubules, intestinal epithelium, and pancreatic islet cells, where it contributes to calcium transport and secretion-related processes. Structurally, Calbindin 1 contains six EF-hand motifs, four of which bind calcium ions with high affinity. Upon calcium binding, the protein undergoes conformational changes that enable interactions with signaling molecules and influence downstream pathways involved in neurotransmission, synaptic plasticity, and cellular excitability. Altered CALB1 expression has been associated with neurodegenerative disorders including Alzheimer's disease and Parkinson's disease, where impaired calcium homeostasis contributes to neuronal vulnerability. Changes in Calbindin 1 levels have also been described in certain malignancies, highlighting broader biological relevance outside the nervous system. Developmentally, CALB1 expression is dynamically regulated, with distinct patterns observed during embryogenesis and postnatal brain maturation. Because of its stable and cell type-restricted expression pattern, Calbindin 1 antibody serves as a reliable tool for evaluating tissue architecture, neuronal differentiation, and disease-associated alterations in calcium-handling capacity. Clone CALB1/2364 is designed to target Calbindin 1 in research applications and supports detection of Calbindin 1 expression in diverse experimental systems.
Optimal dilution of the Calbindin 1 antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 7-96) was used as the immunogen for this Calbindin 1 antibody.
Store the Calbindin 1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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