- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Related Products
|
Cadherin 6 antibody targets Cadherin 6, also known as K-Cadherin, a calcium-dependent cell-cell adhesion molecule encoded by the CDH6 gene and a member of the classical cadherin family. Cadherin 6 is a single-pass transmembrane glycoprotein primarily localized to the plasma membrane at adherens junctions, where it mediates homophilic interactions between neighboring cells. CDH6 expression is prominent in kidney epithelium, nervous system tissues, and select epithelial compartments, reflecting its role in tissue patterning and morphogenesis.
Functionally, Cadherin 6 contributes to maintenance of epithelial cohesion and cellular organization by linking adjacent cells through calcium-dependent adhesion and coupling to the actin cytoskeleton via catenin complexes. A short functional summary is that CDH6 supports stable cell-cell adhesion required for proper tissue architecture and differentiation. Through these adhesive interactions, K-Cadherin influences cell polarity, migration, and developmental organization.
At the molecular level, Cadherin 6 contains multiple extracellular cadherin repeat domains that mediate calcium binding and adhesive specificity, a transmembrane region, and a conserved cytoplasmic tail that interacts with beta-catenin and other adaptor proteins. These features integrate extracellular adhesion with intracellular signaling pathways. Cadherin 6 antibody reagents are therefore useful for studying adherens junction biology, epithelial development, and changes in adhesion during disease progression. Clone CDH6/3191 is designed to recognize Cadherin 6 and supports consistent detection of CDH6 expression in research applications.
From a biological and disease relevance perspective, altered Cadherin 6 expression has been reported in several cancers, including renal, ovarian, and thyroid carcinomas, where changes in CDH6 levels may be associated with tumor progression and invasive behavior. Cadherin 6 is also investigated in developmental biology due to its regulated expression during organogenesis. CDH6 antibody tools support studies of epithelial differentiation, cancer biology, and cell adhesion dynamics.
Developmentally, Cadherin 6 expression is tightly regulated and contributes to tissue-specific patterning and morphogenetic processes. CDH6 antibodies from NSJ Bioreagents are supplied for research use to support investigations in epithelial biology, development, and translational cancer research.
Optimal dilution of the Cadherin 6 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 250-450) from the human protein was used as the immunogen for the Cadherin 6 antibody.
Aliquot the Cadherin 6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.