Cadherin 2 Antibody / CDH2 / N-Cadherin / CD325 (RQ6245)

Description

Cadherin 2, also known as N-cadherin, is a calcium-dependent cell adhesion protein that plays a crucial role in the formation and maintenance of adherens junctions in various tissues, particularly within the nervous system, heart, and developing embryo. As a member of the classical cadherin superfamily, Cadherin 2 facilitates homophilic cell-cell adhesion, contributing to tissue integrity, morphogenesis, and signal transduction. It is prominently expressed in neurons, cardiac muscle, and mesenchymal cells, where it mediates dynamic cellular interactions during development and repair.

Cadherin 2 has been extensively studied for its involvement in neural development, synaptic plasticity, and epithelial-to-mesenchymal transition (EMT), a process critical to embryogenesis and cancer metastasis. Altered expression or function of Cadherin 2 is associated with several pathologies, including neurodevelopmental disorders, cardiac abnormalities, and invasive cancers. Its regulated expression and adhesive functions make it a valuable biomarker for cell differentiation and tumor progression studies.

The Cadherin 2 antibody is a powerful tool for investigating neural tissue organization, cardiac morphogenesis, and cancer biology. Researchers frequently use Cadherin 2 antibody in applications such as immunohistochemistry, western blot, and immunofluorescence to localize and quantify protein expression. Due to its specificity and reliability, the Cadherin 2 antibody has become essential for both basic research and clinical investigations into cell adhesion and disease mechanisms.

Application Notes

Optimal dilution of the Cadherin 2 antibody should be determined by the researcher.

Immunogen

A human recombinant partial protein (amino acids E170-E266) was used as the immunogen for the Cadherin 2 antibody.

Storage

After reconstitution, the Cadherin 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.