- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
C9 Antibody / Complement component C9 [clone BAO-3] (RQ5006)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ5006 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 449 |
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | BAO-3 |
| Purity | Affinity purified |
| UniProt | P02748 |
| Applications | Western Blot : 1:500-1:2000 Immunohistochemistry (FFPE) : 1:50-1:200 |
| Limitations | This C9/Complement component C9 antibody is available for research use only. |
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C9 antibody recognizes Complement component 9, a secreted glycoprotein encoded by the human C9 gene and a terminal member of the complement cascade. Complement component 9 is a membrane attack complex protein that participates in innate immune defense by forming transmembrane pores in target cells. Complement C9 is synthesized primarily in the liver and circulates in plasma as a soluble monomer before being recruited to sites of complement activation. The C9 antibody is useful for detecting Complement C9 expression in immune and inflammatory contexts where complement activation is involved.
Complement component 9 belongs to the membrane attack complex perforin family of pore forming proteins. Following activation of the classical, lectin, or alternative complement pathways, C5b sequentially associates with C6, C7, and C8 to form the C5b-8 complex, which then recruits multiple C9 molecules. Polymerization of C9 creates a transmembrane channel that disrupts cellular membrane integrity and induces osmotic lysis. A Complement C9 antibody therefore supports studies of terminal complement activation and membrane attack complex deposition in tissues.
C9 is primarily localized extracellularly and within the vascular compartment under physiologic conditions. Tissue deposition is typically observed along cell membranes, particularly in areas of immune complex deposition or antibody mediated cytotoxicity. Complement C9 is highly expressed in hepatocytes as part of the liverâs central role in complement protein production, and it is also detectable in serum, plasma, and inflamed tissues. Increased C9 deposition is frequently observed in autoimmune disorders, transplant rejection, and infectious disease.
The C9 gene is located on chromosome 5p13.1 and encodes a protein that contains the characteristic membrane attack complex perforin domain responsible for pore formation. Structural studies show that upon binding to the assembling membrane attack complex, C9 undergoes conformational rearrangement enabling insertion into lipid bilayers. Dysregulation of complement activation and C9 deposition has been implicated in renal disease, systemic lupus erythematosus, neuromyelitis optica, and other complement mediated pathologies. C9 antibody clone BAO-3 is a recombinant rabbit monoclonal antibody designed to recognize Complement C9 in research applications, supporting evaluation of complement activation and immune mediated tissue injury.
Optimal dilution of the C9/Complement component C9 antibody should be determined by the researcher.
A synthetic peptide specific to human Complement Component C9 was used as the immunogen for the C9/Complement component C9 antibody.
Store the C9/Complement component C9 antibody at -20oC.
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