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- Tel: 858.663.9055
- Email: info@nsjbio.com
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene.
The stated application concentrations are suggested starting points. Titration of the C1QC antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 93-120 from the human protein was used as the immunogen for the C1QC antibody.
Aliquot the C1QC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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