- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
C-X-C Motif Chemokine Receptor 5 Antibody / CD185 [clone CXCR5/13095] (V5993)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5993-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5993-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5993SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | CXCR5/13095 |
| UniProt | P32302 |
| Localization | Cell membrane |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This C-X-C Motif Chemokine Receptor 5/CD185 antibody is available for research use only. |
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C-X-C Motif Chemokine Receptor 5 antibody, also known as CD185 antibody, recognizes C-X-C motif chemokine receptor 5, a seven-transmembrane G protein-coupled receptor encoded by the CXCR5 gene and commonly referred to as Burkitt lymphoma receptor 1. C-X-C Motif Chemokine Receptor 5 is primarily localized to the plasma membrane of B lymphocytes and subsets of T cells, particularly follicular helper T cells, where it regulates chemokine-driven cell migration. As a member of the CXC chemokine receptor family, CXCR5 binds the ligand CXCL13 and plays a central role in lymphoid follicle organization and germinal center formation.
C-X-C Motif Chemokine Receptor 5 antibody detects a multi-pass transmembrane receptor composed of seven alpha-helical membrane-spanning domains, extracellular regions responsible for ligand recognition, and intracellular domains that couple to heterotrimeric G proteins. Upon binding CXCL13, CXCR5 activates downstream signaling pathways that promote cytoskeletal rearrangement and directed chemotaxis. Through these mechanisms, CD185 directs B cells and T follicular helper cells into B cell follicles within secondary lymphoid tissues, supporting antibody affinity maturation and adaptive immune responses.
Functionally, CXCR5 is essential for proper germinal center architecture and humoral immunity. Expression of C-X-C Motif Chemokine Receptor 5 defines follicular B cells and T follicular helper cells and is widely used as a marker in immunophenotyping and lymphoid tissue studies. Dysregulated CXCR5 signaling has been implicated in autoimmune diseases, chronic inflammatory conditions, and lymphoid malignancies. In certain B cell lymphomas, altered CD185 expression may influence tumor cell positioning and interactions within the lymphoid microenvironment.
The CXCR5 gene is located on chromosome 11 and is transcriptionally regulated during lymphocyte activation and differentiation. Because C-X-C Motif Chemokine Receptor 5 expression is largely restricted to specific immune cell subsets, detection of this receptor provides insight into lymphocyte trafficking, germinal center dynamics, and immune cell compartmentalization in normal and disease contexts.
The C-X-C Motif Chemokine Receptor 5 antibody (clone CXCR5/13095) is suitable for detecting CXCR5 protein expression in research applications. This CD185 antibody supports investigation of B cell biology, T follicular helper cell function, lymphoid tissue organization, and immune-mediated disease mechanisms.
Optimal dilution of the C-X-C Motif Chemokine Receptor 5/CD185 antibody should be determined by the researcher.
A recombinant fragment of human CXCR5 protein (exact sequence is proprietary) was used as the immunogen for the C-X-C Motif Chemokine Receptor 5/CD185 antibody.
C-X-C Motif Chemokine Receptor 5/CD185 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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