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Home >> Antibodies >> c-RET Antibody / RET Tyrosine Kinase Receptor

c-RET Antibody / RET Tyrosine Kinase Receptor [clone RET/8789] (V4092)

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  Catalog No Formulation Size Price (USD)  
Image V4092-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 559
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V4092-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 259
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V4092SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
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Immunohistochemistry analysis of c-RET / RET Tyrosine Kinase Receptor antibody (clone RET/8789) in human parathyroid tissue. FFPE human parathyroid demonstrates diffuse membranous and cytoplasmic HRP-DAB brown staining in parathyroid epithelial cells, consistent with RET expression. Staining is strong and relatively uniform across the glandular cell population, with clear membrane accentuation outlining individual cells. Stromal elements show comparatively weaker signal. Nuclei are counterstained blue. Heat induced epitope retrieval was performed by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 20 minutes followed by cooling prior to immunostaining.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Host Mouse
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2c, kappa
Clone Name RET/8789
Purity Protein A/G affinity
UniProt P07949
Localization Cytoplasmic, nuclear, cell surface
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This c-RET/RET Tyrosine Kinase Receptor antibody is available for research use only.
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Description

c-RET antibody recognizes RET tyrosine kinase receptor, a membrane-spanning receptor involved in neurotrophic and oncogenic signaling. RET is activated through ligand-induced dimerization, leading to autophosphorylation of key tyrosine residues within its intracellular kinase domain. These phosphorylation events create docking sites for adaptor proteins that initiate downstream signaling cascades including MAPK, AKT, and STAT pathways.

RET tyrosine kinase receptor is critical for development of the enteric nervous system, kidney morphogenesis, and neuronal survival. Genetic alterations affecting RET, including point mutations and chromosomal rearrangements, result in constitutive kinase activation and contribute to multiple endocrine neoplasia type 2 and various thyroid and lung cancers. The receptor exists as multiple isoforms generated through alternative splicing, which may influence signaling output and cellular localization.

c-RET antibody is suitable for detecting RET tyrosine kinase receptor expression in studies focused on kinase biology, receptor activation, and targeted inhibition strategies. Monitoring RET levels assists in understanding signaling alterations associated with malignancy and developmental disorders.

Application Notes

Optimal dilution of the c-RET/RET Tyrosine Kinase Receptor antibody should be determined by the researcher.

Immunogen

A recombinant partial protein (within amino acids 702-848) from the human protein was used as the immunogen for the c-RET/RET Tyrosine Kinase Receptor antibody.

Storage

Aliquot the c-RET/RET Tyrosine Kinase Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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