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Home >> Antibodies >> c-RET Antibody / MEN2-Associated RET Protein

c-RET Antibody / MEN2-Associated RET Protein [clone RET/7694] (V4094)

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  Catalog No Formulation Size Price (USD)  
Image V4094-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 559
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V4094-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 259
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V4094SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
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Immunohistochemistry analysis of c-RET / MEN2-Associated RET Protein antibody (clone RET/7694) in human parathyroid gland tissue. FFPE human parathyroid demonstrates strong membranous and cytoplasmic HRP-DAB brown staining in parathyroid epithelial cells, consistent with RET expression. Staining is diffuse and uniform across the glandular cell population with clear membrane accentuation outlining individual cells, while surrounding stromal components show comparatively weaker signal. Nuclei are counterstained blue. Heat induced epitope retrieval was performed by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 20 minutes followed by cooling prior to immunostaining.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Host Mouse
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2, kappa
Clone Name RET/7694
Purity Protein A/G affinity
UniProt P07949
Localization Cytoplasm, Cell Surface, Nucleus
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This c-RET/MEN2-Associated RET Protein antibody is available for research use only.
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Description

c-RET antibody recognizes MEN2-associated RET protein, a receptor tyrosine kinase implicated in multiple endocrine neoplasia type 2. Germline activating mutations in the RET gene drive constitutive kinase activation, leading to medullary thyroid carcinoma, pheochromocytoma, and parathyroid hyperplasia characteristic of MEN2 syndromes. RET signaling activates MAPK and PI3K-AKT pathways that promote cellular proliferation and survival.

MEN2-associated RET protein mutations frequently occur within the extracellular cysteine-rich domain or intracellular kinase domain, resulting in ligand-independent receptor activation. In addition to hereditary syndromes, somatic RET alterations are observed in sporadic thyroid and lung cancers. Physiologically, RET contributes to neural crest cell migration, kidney development, and neuronal differentiation.

c-RET antibody is suitable for detecting MEN2-associated RET protein in cancer research and studies of endocrine tumor biology. Analysis of RET expression supports investigation of oncogenic kinase activation and therapeutic targeting strategies in RET-driven malignancies.

Application Notes

Optimal dilution of the c-RET/MEN2-Associated RET Protein antibody should be determined by the researcher.

Immunogen

A recombinant partial protein (within amino acids 702-848) from the human protein was used as the immunogen for the c-RET/MEN2-Associated RET Protein antibody.

Storage

Aliquot the c-RET/MEN2-Associated RET Protein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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