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Home >> Antibodies >> c-Myb Antibody [Discontinued, view alternative antibodies]

c-Myb Antibody [Discontinued, view alternative antibodies] [clone MYB286] (V3123)

  Catalog No Formulation Size Price (USD)  
Image V3123-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3123-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3123SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Availability Discontinued
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name MYB286
Purity Protein G affinity chromatography
UniProt P01104
Localization Nuclear
Applications ELISA : 2-4ug/ml (order BSA/azide-free format)
Limitations This c-Myb antibody is available for research use only.
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Description

The highly leukemogenic avian retrovirus E26 contains two oncogenes, v-Myb and v-Ets, which are expressed together as a fusion protein. The cellular homolog of v-Myb, designated c-Myb, encodes a transcription factor. Deletion or disruption of a negative regulatory domain mapping within the carboxy-terminal domain of c-Myb results in enhanced transactivating capacity and in parallel, leads to activation of its ability to transform hemopoietic cells. c-Myb is expressed preferentially, but not exclusively, in immature hemopoietic cells and its expression decreases as cells differentiate.

Application Notes

The optimal dilution of the c-Myb antibody for each application should be determined by the researcher.

Immunogen

Amino acids 119-135 (RRKVEQEGYPQESSKAG) from the human protein were used as the immunogen for this c-Myb antibody.

Storage

Store the c-Myb antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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