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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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c-Kit Antibody KIT/982 / KIT Monoclonal Antibody recognizes KIT, a receptor tyrosine kinase also known as CD117 and the stem cell factor receptor. KIT belongs to the type III receptor tyrosine kinase family, which also includes related receptors such as PDGF receptors and FLT3. The KIT protein contains an extracellular ligand-binding region, a single transmembrane segment and an intracellular split tyrosine kinase domain that mediates signal transduction following receptor activation.
Stem cell factor is the principal ligand for KIT. Ligand binding promotes receptor dimerization and activation of the intracellular kinase domain, followed by phosphorylation of specific tyrosine residues. Activated KIT recruits signaling proteins that connect the receptor with pathways including PI3K/AKT and RAS/MAPK. These signaling networks regulate cellular proliferation, survival, differentiation and migration in several developmentally important cell populations.
KIT is particularly important in hematopoietic progenitor cells, mast cells, melanocytes and germ cells. Normal KIT signaling contributes to hematopoiesis, mast cell development, pigmentation and gametogenesis. The CD117 designation is also widely used when identifying and characterizing hematopoietic and progenitor cell populations, making KIT an extensively investigated marker in developmental and cellular biology.
Abnormal KIT activity has important roles in cancer biology. Activating mutations can produce ligand-independent kinase signaling and occur prominently in gastrointestinal stromal tumors as well as subsets of other malignancies. KIT expression and signaling are consequently investigated in studies of oncogenic receptor activation, tumor biology and responses to targeted kinase inhibitors.
NSJ Bioreagents offers c-Kit Antibody clone KIT/982 for research into KIT expression and stem cell factor receptor biology. The KIT Monoclonal Antibody terminology reflects the official gene designation and provides a complementary search term to the widely used c-Kit protein name.
A c-Kit Antibody provides a reagent for investigating KIT expression, stem cell factor signaling, hematopoietic development and receptor biology in normal and disease-associated processes.
For a Protein Microarray Validated CD117 antibody with GIST IHC validation, see our CD117 Antibody C117/6347 / c-Kit Monoclonal Antibody.
Optimal dilution of the c-Kit Antibody KIT/982 / KIT Monoclonal Antibody should be determined by the researcher.
A recombinant human fragment around amino acids 100-300 was used as the immunogen for the c-Kit Antibody KIT/982.
Store the c-Kit Antibody KIT/982 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
KIT antibody, CD117 antibody, Stem Cell Factor Receptor antibody, SCFR antibody, Mast/Stem Cell Growth Factor Receptor Kit antibody
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