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Home >> Antibodies >> c-Fos Antibody

c-Fos Antibody (R30378)

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  Catalog No Formulation Size Price (USD)  
Image R30378 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of c-Fos antibody and Lane 1: HT1080; 2: COLO320 cell lysate. Expected molecular weight: ~40 kDa (unmodified), 53-68 kDa (phosphorylated).
Western blot testing of c-Fos antibody and Lane 1: HT1080; 2: COLO320 cell lysate. Expected molecular weight: ~40 kDa (unmodified), 53-68 kDa (phosphorylated).
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P01100
Applications Western blot : 0.5-1ug/ml
Limitations This c-Fos antibody is available for research use only.
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Description

The human oncogene c-Fos is the cellular homolog of the transforming gene of Finkel-Biskis-Jinkins(FBJ) murine osteosarcoma virus which was mapped to a single human chromosome. The protein is encoded by the FOS gene. It was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family. c-Fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation. Using transgenic and knockout mice, Grigoriadis et al.(1995) established a unique role for the proto-oncogene and nuclear transcription factor in regulating the differentiation and activity of specific bone cell populations, both during normal development and in bone disease.

Application Notes

The stated application concentrations are suggested starting points. Titration of the c-Fos antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Amino acids 170-187 (DQLEDEKSALQTEIANLL) were used as the immunogen for this c-Fos antibody (100% homologous in human, mouse and rat).

Storage

After reconstitution, the c-Fos antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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