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Home >> Antibodies >> BTLA Antibody / CD272

BTLA Antibody / CD272 [clone BTLA/1528] (V7708)

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  Catalog No Formulation Size Price (USD)  
Image V7708-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7708-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V7708SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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SDS-PAGE analysis of purified, BSA-free BTLA antibody (clone BTLA/1528) as confirmation of integrity and purity.
SDS-PAGE analysis of purified, BSA-free BTLA antibody (clone BTLA/1528) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name BTLA/1528
Purity Protein G affinity chromatography
Applications ELISA (order BSA-free format for coating) :
Limitations This BTLA antibody is available for research use only.
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Description

B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T-cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are coinhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T-cell activation by propagating inhibitory signals through BTLA. The BTLAHVEM interaction is conserved between Mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.

Application Notes

Optimal dilution of the BTLA antibody should be determined by the researcher.

Immunogen

Recombinant extracellular human CD272/BTLA protein was used as the immunogen for this BTLA antibody.

Storage

Store the BTLA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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