- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GTF2H2 Antibody / TFIIH p44 Antibody [clone PCRP-GTF2H2-1B9] (V9196)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9196-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9196-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9196SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1 |
| Clone Name | PCRP-GTF2H2-1B9 |
| Purity | Protein A/G affinity |
| UniProt | Q13888 |
| Localization | Nucleus |
| Applications | Flow Cytometry : 1-2ug/million cells Immunofluorescence : 1-2ug/ml |
| Limitations | This GTF2H2 Antibody / TFIIH p44 Antibody is available for research use only. |
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GTF2H2 Antibody / TFIIH p44 Antibody recognizes GTF2H2, the p44 subunit of general transcription factor IIH (TFIIH), a multiprotein complex with essential functions in RNA polymerase II transcription and nucleotide excision repair. GTF2H2 is a component of the TFIIH core complex and contributes to the molecular machinery responsible for transcription initiation and repair of damaged DNA. The protein is also historically known as BTF2 p44 or BTF2P44.
During RNA polymerase II-dependent transcription, TFIIH is recruited to the transcription preinitiation complex assembled at gene promoters. TFIIH participates in promoter opening and promoter escape, enabling RNA polymerase II to transition into productive transcription. GTF2H2 contributes to TFIIH function through interactions with other components of the complex, including the XPD helicase encoded by ERCC2. Its N-terminal region interacts with and regulates XPD, while the C-terminal portion contributes to successful RNA polymerase II promoter escape.
TFIIH also has a central role in nucleotide excision repair, a DNA repair pathway responsible for removing bulky, helix-distorting DNA lesions. The TFIIH core complex participates in both global genome and transcription-coupled nucleotide excision repair, helping open DNA surrounding a lesion so the damaged oligonucleotide can be excised and replaced. The dual involvement of GTF2H2 in transcription and DNA repair makes it relevant to studies of basal transcription, transcription factor assembly, genomic stability, DNA damage responses and nucleotide excision repair.
Clone PCRP-GTF2H2-1B9 is a mouse monoclonal antibody generated against full-length recombinant human GTF2H2 protein and purified by Protein A/G affinity chromatography. The antibody has also been evaluated on a HuProt protein microarray containing more than 19,000 full-length human proteins. NSJ Bioreagents provides this GTF2H2 Antibody for research into TFIIH biology, transcription and DNA repair. A TFIIH p44 Antibody can support investigation of the p44 subunit and its contribution to transcription initiation and nucleotide excision repair.
Explore our Transcription Factor Antibodies page for additional reagents targeting proteins involved in transcription initiation, transcriptional regulation and gene expression.
Optimal dilution of the GTF2H2 Antibody / TFIIH p44 Antibody should be determined by the researcher.
Recombinant full-length human GTF2H2 protein was used as the immunogen for the GTF2H2 Antibody.
Aliquot the GTF2H2 Antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
GTF2H2 antibody, TFIIH p44 antibody, BTF2 p44 antibody, general transcription factor IIH subunit 2 antibody, BTF2P44 antibody
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