- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
BRCA1-Associated Protein 1 Antibody / BAP1 (RQ6826)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ6826 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q92560 |
| Localization | Nuclear, cytoplasmic |
| Applications | Western Blot : 1-2ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml Immunofluorescence : 5ug/ml |
| Limitations | This BRCA1-Associated Protein 1 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
BRCA1-associated protein 1 antibody targets BRCA1-associated protein 1, a nuclear deubiquitinating enzyme encoded by the BAP1 gene. BRCA1-associated protein 1 belongs to the ubiquitin C-terminal hydrolase family and functions as a key regulator of chromatin organization, transcriptional control, and DNA damage response pathways. Initially identified through its interaction with the BRCA1 tumor suppressor, BRCA1-associated protein 1 has since been established as an important component of epigenetic regulation and genome stability across diverse cellular systems.
Functionally, BRCA1-associated protein 1 removes ubiquitin from specific protein substrates, including histone H2A and other chromatin-associated proteins. Through these deubiquitinating activities, BAP1 modulates chromatin accessibility and transcriptional output, thereby influencing gene expression programs involved in cell cycle regulation, cellular differentiation, and stress response pathways. BRCA1-associated protein 1 operates within multiprotein chromatin-regulatory complexes that integrate ubiquitin signaling with transcriptional machinery and DNA repair processes. A BRCA1-associated protein 1 antibody supports studies focused on ubiquitin-dependent signaling, chromatin remodeling, and transcriptional regulation in both normal and disease-associated cellular contexts.
Beyond its catalytic role, BRCA1-associated protein 1 serves as a structural and regulatory component within chromatin-associated protein assemblies. These complexes coordinate interactions between histones, transcriptional regulators, and DNA repair factors, allowing BAP1 to influence multiple layers of nuclear organization. Through these interactions, BRCA1-associated protein 1 contributes to maintenance of chromatin integrity and proper regulation of gene expression programs that are essential for cellular homeostasis. Disruption of these regulatory networks can result in altered transcriptional states and impaired genomic maintenance.
BRCA1-associated protein 1 is broadly expressed in human tissues, with particularly important roles in proliferative, metabolically active, and differentiating cells. Subcellular localization is predominantly nuclear, consistent with its chromatin-associated functions, and is mediated by defined nuclear localization sequences. In certain cellular contexts, including transformed cells or cells experiencing genotoxic stress, cytoplasmic localization of BAP1 has also been reported, suggesting dynamic regulation of its distribution. These localization patterns reflect the involvement of BRCA1-associated protein 1 in adaptive cellular responses rather than a fixed structural role.
At the molecular level, BRCA1-associated protein 1 contains a conserved catalytic domain required for deubiquitinating activity, along with additional regions that mediate protein-protein interactions within chromatin-modifying and transcriptional complexes. These structural features allow BAP1 to function as an integrator of ubiquitin signaling and epigenetic regulation rather than as an isolated enzymatic factor. Post-translational modifications and interaction-dependent regulation further contribute to context-specific BAP1 activity and localization.
From a disease relevance perspective, BRCA1-associated protein 1 is a well-established tumor suppressor. Loss or inactivation of BAP1 has been implicated in multiple malignancies, including mesothelioma, uveal melanoma, renal cell carcinoma, and other solid tumors. Germline and somatic alterations in the BAP1 gene are associated with increased cancer susceptibility, altered transcriptional regulation, and aggressive disease phenotypes. These findings highlight the importance of BRCA1-associated protein 1-mediated ubiquitin regulation in maintaining genomic stability and controlled cell growth. BRCA1-associated protein 1 antibody reagents support research applications examining epigenetic control mechanisms, DNA damage signaling, tumor suppressor pathways, and chromatin-associated regulatory processes, with NSJ Bioreagents providing reagents intended for research use.
Optimal dilution of the BRCA1-Associated Protein 1 antibody should be determined by the researcher.
Recombinant human protein (amino acids E7-Q702) was used as the immunogen for the BRCA1-Associated Protein 1 antibody.
After reconstitution, the BRCA1-Associated Protein 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
