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Home >> Antibodies >> BRCA1-Associated Protein 1 Antibody / BAP1

BRCA1-Associated Protein 1 Antibody / BAP1 [clone BAP1/8959R] (V4969)

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  Catalog No Formulation Size Price (USD)  
Image V4969-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4969-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4969SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human breast carcinoma tissue with BRCA1-Associated Protein 1 antibody (clone BAP1/8959R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human breast carcinoma tissue with BRCA1-Associated Protein 1 antibody (clone BAP1/8959R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human breast carcinoma tissue with BRCA1-Associated Protein 1 antibody (clone BAP1/8959R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name BAP1/8959R
Purity Protein A/G affinity
UniProt Q92560
Localization Nucleus, Cytoplasm
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This BRCA1-Associated Protein 1 antibody is available for research use only.
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Description

The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.

Application Notes

Optimal dilution of the BRCA1-Associated Protein 1 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 630-729) from the human protein was used as the immunogen for the BRCA1-Associated Protein 1 antibody.

Storage

Aliquot the BRCA1-Associated Protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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