- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
BRAF Antibody [clone CCG-2] (RQ5438)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ5438 | Antibody in PBS with 0.02% sodium azide and 50% glycerol | 100 ul | 429 |
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | CCG-2 |
| Purity | Affinity purified |
| UniProt | P15056 |
| Localization | Cytoplasmic, nuclear, cell membrane |
| Applications | Western blot : 1:500-1:2000 Immunohistochemistry (FFPE) : 1:50-1:200 |
| Limitations | This BRAF antibody is available for research use only. |
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The BRAF gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. [RefSeq]
Optimal dilution of the BRAF antibody should be determined by the researcher.
A synthetic peptide specific to human B Raf was used as the immunogen for the BRAF antibody.
Store the BRAF antibody at -20oC.
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