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Home >> Antibodies >> BMP4 Antibody / Bone morphogenetic protein 4

BMP4 Antibody / Bone morphogenetic protein 4 [clone BBB-2] (RQ5387)

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  Catalog No Formulation Size Price (USD)  
Image RQ5387 Antibody in PBS with 0.02% sodium azide and 50% glycerol 100 ul 429
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IHC staining of FFPE human breast cancer with BMP4 antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
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IHC staining of FFPE human breast cancer with BMP4 antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
Western blot testing of human HeLa cell lysate with BMP4 antibody. Expected molecular weight: 54 kDa (precursor), 44 kDa (cleaved dimer), 23 kDa (cleaved monomer).
Availability 1-2 weeks
Species Reactivity Human
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name BBB-2
Purity Affinity purified
UniProt P12644
Applications Western blot : 1:500-1:2000
Immunohistochemistry (FFPE) : 1:50-1:200
Limitations This BMP4 antibody is available for research use only.
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Description

The BMP4 gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [RefSeq]

Application Notes

Optimal dilution of the BMP4 antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to human BMP4 was used as the immunogen for the BMP4 antibody.

Storage

Store the BMP4 antibody at -20oC.

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