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Home >> Antibodies >> BLyS Antibody / BAFF

BLyS Antibody / BAFF (RQ5555)

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  Catalog No Formulation Size Price (USD)  
Image RQ5555 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) U-937, 2) Caco-2, 3) PANC-1, 4) CCRF-CEM, 5) MDA-MB-231 lysate with BLyS antibody. Predicted molecular weight ~34 kDa.
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Western blot testing of human 1) U-937, 2) Caco-2, 3) PANC-1, 4) CCRF-CEM, 5) MDA-MB-231 lysate with BLyS antibody. Predicted molecular weight ~34 kDa.
Western blot testing of 1) rat testis and 2) mouse testis lysate with BLyS antibody. Predicted molecular weight ~34 kDa.
Flow cytometry testing of human HL60 cells with BLyS antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= BLyS antibody.
Flow cytometry testing of human U-87 MG cells with BLyS antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= BLyS antibody.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt Q9Y275
Applications Western blot : 0.25-0.5ug/ml
Flow cytometry : 1-3ug/million cells
Direct ELISA : 0.1-0.5ug/ml
Limitations This BLyS antibody is available for research use only.
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Description

BLyS / BAFF was regularly detected by enzyme-linked immunosorbent assay in brain tissue lysates and in normal spinal fluid, and in astrocytes by double fluorescence microscopy. BAFF was localized in astrocytes close to BAFF-R-expressing immune cells. BAFF receptors were strongly expressed in situ in primary central nervous system (CNS) lymphomas. The TNF superfamily member B cell-activating factor (BAFF) plays an important role in humoral immunity and in autoimmune diseases, including RA. Local BAFF gene targeting inhibited proinflammatory cytokine expression, suppressed generation of plasma cells and Th17 cells, and markedly ameliorated joint pathology. The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R).

Application Notes

Optimal dilution of the BLyS antibody should be determined by the researcher.

Immunogen

A human recombinant protein (amino acids A134-T277) was used as the immunogen for the BLyS antibody.

Storage

After reconstitution, the BLyS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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