- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Bim Antibody / Bcl-2-like protein 11 (FY13189)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13189 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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Bim antibody detects Bcl-2-like protein 11, a pro-apoptotic member of the Bcl-2 family that promotes programmed cell death through mitochondrial outer membrane permeabilization. The UniProt recommended name is Bcl-2-like protein 11 (BCL2L11). Also known as Bim, this BH3-only protein is a critical initiator of apoptosis in response to cellular stress, cytokine withdrawal, or DNA damage.
Functionally, Bim antibody identifies a 198-amino-acid cytoplasmic protein that binds anti-apoptotic Bcl-2 proteins (such as BCL2, BCL-XL, and MCL1), releasing pro-apoptotic effectors BAX and BAK to trigger mitochondrial cytochrome c release and caspase activation. Bim exists in several isoforms (BimEL, BimL, and BimS) generated by alternative splicing, which modulate apoptosis sensitivity across cell types.
The BCL2L11 gene is located on chromosome 2q13 and is expressed in lymphoid, neuronal, and epithelial tissues. Its expression is tightly regulated by survival pathways including PI3K/AKT and MAPK signaling, which control phosphorylation and proteasomal degradation of Bim.
Pathologically, dysregulation of Bim contributes to cancer, autoimmune diseases, and neurodegeneration. Reduced Bim expression confers resistance to apoptosis in tumor cells, while overexpression causes excessive neuronal death. Research using Bim antibody supports studies in cell death signaling, oncology, and stress-induced apoptosis.
Bim antibody is validated for western blotting, immunohistochemistry, and apoptosis assays to detect Bcl-2 family proteins. NSJ Bioreagents provides Bim antibody reagents optimized for apoptosis research, mitochondrial biology, and cancer cell signaling.
Structurally, Bcl-2-like protein 11 contains a BH3 domain required for binding to anti-apoptotic Bcl-2 members and activating the intrinsic apoptotic pathway. This antibody supports exploration of Bims role in stress-induced mitochondrial apoptosis and cellular homeostasis.
Optimal dilution of the Bim antibody should be determined by the researcher.
E.coli-derived mouse Bim/Bcl2l11 recombinant protein (Position: Q18-R186) was used as the immunogen for the Bim antibody.
After reconstitution, the Bim antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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