- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Beta-Nerve Growth Factor Antibody / Neurotrophic Signaling Antibody (F54948)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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F54948-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 439 | |
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F54948-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 205 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Purified |
| UniProt | P01138 |
| Localization | Cytoplasmic, secreted |
| Applications | Immunofluorescence : 1:10-1:50 Flow Cytometry : 1:10-1:50 (1x10e6 cells) Immunohistochemistry (FFPE) : 1:10-1:50 Western Blot : 1:500-1:1000 |
| Limitations | This Beta-Nerve Growth Factor Antibody / Neurotrophic Signaling Antibody is available for research use only. |
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Nerve growth factor (NGF) is a secreted neurotrophin encoded by the NGF gene that plays a central role in neuronal survival, neurite outgrowth, synaptic plasticity, and peripheral nervous system maintenance. Beta-Nerve Growth Factor Antibody / Neurotrophic Signaling Antibody is useful for investigating mature NGF-associated signaling pathways involved in neuronal differentiation, tissue repair, and neuroimmune communication. Beta-Nerve Growth Factor antibody, also referred to as Beta NGF antibody, NGF beta antibody, or Mature NGF antibody in the literature, recognizes the biologically active neurotrophin form responsible for canonical TrkA receptor activation and downstream neuronal survival signaling. This rabbit polyclonal antibody supports detection of NGF expression patterns across neurobiology, regeneration, and inflammation-related research models.
NGF is initially synthesized as a precursor protein known as proNGF that undergoes proteolytic cleavage to generate mature beta-NGF. Mature NGF preferentially binds the high-affinity TrkA receptor, activating intracellular signaling pathways including MAPK/ERK, PI3K-AKT, and PLC-gamma cascades that regulate neuronal maintenance and differentiation. In contrast, proNGF may participate in p75NTR-associated apoptotic signaling under selected physiologic and disease-associated conditions. Because mature and precursor NGF forms possess distinct biological activities, antibodies directed toward beta-NGF are important tools for studying neurotrophin processing and signaling balance.
Beta-NGF is highly expressed in neuronal and peripheral nerve-associated tissues and may also be detected in epithelial cells, stromal compartments, inflammatory microenvironments, and endocrine-associated tissues. Increased NGF expression has been associated with tissue injury, chronic inflammation, wound healing, and peripheral nerve regeneration. Elevated NGF signaling contributes to nociceptor sensitization and chronic pain biology through enhanced neuroimmune crosstalk involving mast cells, macrophages, and sensory neurons. NGF additionally participates in neuronal adaptation mechanisms linked to oxidative stress and ischemic injury responses.
In cancer biology, NGF-TrkA signaling has been implicated in tumor cell survival, angiogenesis, neural invasion, and tumor microenvironment remodeling in several malignancies including prostate cancer, pancreatic cancer, breast cancer, and neural crest-derived tumors. Increased neurotrophin signaling has also been explored in neurodegenerative disease models involving Alzheimer's disease, Parkinsonian syndromes, spinal cord injury, and diabetic neuropathy. Because beta-NGF represents the mature signaling form of Nerve growth factor, detection reagents targeting this pathway are widely used in translational neuroscience and regenerative medicine research.
At the cellular level, beta-NGF is commonly localized within cytoplasmic secretory vesicles and peptide-processing compartments associated with intracellular trafficking and extracellular release. Immunofluorescence analysis frequently demonstrates punctate cytoplasmic staining patterns consistent with secretory pathway localization. In tissue sections, NGF expression may be observed in neurons, peripheral nerve fibers, glandular epithelium, injury-responsive stromal cells, and inflammatory cell populations depending on tissue type and physiologic state. This rabbit polyclonal Beta-Nerve Growth Factor antibody provides a useful approach for investigating mature neurotrophin expression and neurotrophic signaling mechanisms across diverse experimental systems.
Our NGF Antibody / Neurotrophin Signaling Marker Antibody page highlights clone BDE-14 for detection of Nerve growth factor expression in neuronal signaling, neurodevelopment, tissue repair, and neurodegeneration research applications.
The stated application concentrations are suggested starting points. Titration of the Beta-Nerve Growth Factor Antibody / Neurotrophic Signaling Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 84-115 from the human protein was used as the immunogen for the Beta-Nerve Growth Factor Antibody.
Aliquot the Beta-Nerve Growth Factor Antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Beta NGF antibody, NGF beta antibody, Mature NGF antibody, Nerve growth factor beta antibody, Neurotrophin antibody
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