- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Beta-Myosin Heavy Chain Antibody / MYH7 [clone MYH7/9969R] (V5955)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5955-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5955-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5955SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | MYH7/9969R |
| UniProt | P12883 |
| Localization | Cytoplasm, Myofibril |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 2-4ug/ml |
| Limitations | This Beta-Myosin Heavy Chain/MYH7 antibody is available for research use only. |
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Beta-Myosin Heavy Chain antibody (clone MYH7/9969R) targets the beta-myosin heavy chain protein encoded by the human MYH7 gene, a major sarcomeric motor protein expressed in cardiac muscle and type I slow-twitch skeletal muscle fibers. Beta-myosin heavy chain, also commonly referred to as MYH7 or Myosin 7 in molecular and clinical literature, plays a central role in contractile force generation within the sarcomere. Beta-Myosin Heavy Chain antibody is widely used in cardiovascular and skeletal muscle research because MYH7 expression defines ventricular myocardium and slow oxidative muscle fibers.
The MYH7 gene encodes the beta-myosin heavy chain isoform that predominates in human ventricular cardiac muscle and in type I slow skeletal muscle fibers. The protein forms thick filaments that interact with actin filaments through ATP-dependent motor activity to produce muscle contraction. Beta-Myosin Heavy Chain antibody clone MYH7/9969R is a recombinant monoclonal antibody developed for consistent detection of MYH7 expression in cardiac and skeletal muscle tissues in research applications.
Mutations in MYH7 are strongly associated with inherited cardiomyopathies, including hypertrophic cardiomyopathy and dilated cardiomyopathy, as well as certain skeletal myopathies. Altered MYH7 expression and isoform switching are observed in cardiac remodeling, heart failure, and developmental transitions in muscle fiber composition. Because of its importance in sarcomere integrity and cardiac performance, Beta-Myosin Heavy Chain antibody supports investigation of contractile machinery and muscle disease mechanisms.
Structurally, beta-myosin heavy chain contains a globular head domain responsible for ATP hydrolysis and actin binding, a neck region that associates with regulatory light chains, and a long coiled-coil tail that mediates thick filament assembly. As a recombinant monoclonal antibody, clone MYH7/9969R provides defined sequence consistency for detecting MYH7 expression in cardiac and slow skeletal muscle tissues in research settings.
1. Optimal dilution of the Beta-Myosin Heavy Chain/MYH7 antibody should be determined by the researcher.
2. This Beta-Myosin Heavy Chain/MYH7 antibody is recombinantly produced by expression in CHO cells.
A recombinant fragment (around amino acids 1150-1350) of human MYH7 protein (exact sequence is proprietary) was used as the immunogen for the Beta-Myosin Heavy Chain/MYH7 antibody.
Beta-Myosin Heavy Chain/MYH7 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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