- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Beta Catenin Antibody [clone 15B8] (V3248)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V3248-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
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V3248-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
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V3248SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | 15B8 |
| Purity | Protein G affinity chromatography |
| UniProt | P35222 |
| Localization | Cell surface, cytoplasmic, cell junctions |
| Applications | Flow Cytometry : 1-2ug/10^6 cells Immunofluorescence : 1-3ug/ml Western Blot : 2-4ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Beta Catenin antibody is available for research use only. |
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Beta Catenin antibody is widely used for research on cellular adhesion and Wnt pathway signaling. Beta catenin, encoded by CTNNB1, is a versatile protein that stabilizes cell cell contacts and also acts as a transcriptional regulator. This dual functionality makes it central to processes ranging from embryonic development to tumorigenesis. Its dysregulation is strongly associated with oncogenic transformation and uncontrolled proliferation.
In adherens junctions, beta catenin interacts with cadherins and alpha catenin to maintain epithelial structure and facilitate communication between cells. When signaling pathways are activated, beta catenin can accumulate in the cytoplasm and translocate into the nucleus. There it interacts with transcription factors to activate genes critical for cell cycle progression and survival. This dynamic shuttling between structural and signaling roles highlights why beta catenin is a major regulator of cellular homeostasis.
The Beta Catenin antibody clone 15B8 is recognized for its reliable specificity and performance. Clone 15B8 has been employed to examine how beta catenin localization changes under different signaling conditions, shedding light on pathways controlling proliferation and differentiation. Researchers use this antibody to study embryonic development, tissue regeneration, and the mechanisms underlying oncogenic transformation. The robustness of clone 15B8 ensures dependable results across diverse experimental models.
Beta catenin dysregulation is commonly driven by mutations that stabilize the protein or impair its degradation. In colorectal cancer and other malignancies, these changes lead to persistent nuclear signaling and enhanced expression of growth promoting genes. Studies employing clone 15B8 have been instrumental in understanding how abnormal Wnt signaling drives tumor initiation and progression. Beyond oncology, beta catenin is also critical for bone formation, cardiovascular development, and neural patterning, emphasizing its diverse biological relevance.
NSJ Bioreagents offers this Beta Catenin antibody to researchers investigating adhesion, signaling, and cancer. The protein is also referenced by alternate names including CTNNB1 antibody, cadherin associated protein beta antibody, armadillo protein antibody, and cell adhesion molecule associated protein antibody. Integrating these terms ensures recognition of the many ways scientists describe this versatile regulator in their studies.
Optimal dilution of the Beta Catenin antibody to be determined by the researcher.
Chicken recombinant protein was used as the immunogen for the Beta Catenin antibody.
Store the Beta Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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