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Home >> Antibodies >> Bestrophin 1 Antibody

Bestrophin 1 Antibody (RQ4302)

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  Catalog No Formulation Size Price (USD)  
Image RQ4302 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) A549, 2) SGC-7901 and 3) U-2 OS cell lysate with Bestrophin 1 antibody at 0.5ug/ml. Predicted molecular weight ~68 kDa.
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Western blot testing of human 1) A549, 2) SGC-7901 and 3) U-2 OS cell lysate with Bestrophin 1 antibody at 0.5ug/ml. Predicted molecular weight ~68 kDa.
Flow cytometry testing of human HeLa cells with Bestrophin 1 antibody at 1ug/10^6 cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue=Bestrophin 1 antibody.
Flow cytometry testing of human LoVo cells with Bestrophin 1 antibody at 1ug/10^6 cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue=Bestrophin 1 antibody.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt O76090
Localization Cell membrane
Applications Western blot : 0.5-1ug/ml
Flow Cytometry : 1-3ug/10^6 cells
Limitations This Bestrophin 1 antibody is available for research use only.
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Description

Bestrophin-1 (Best1) is a protein that, in humans, is encoded by the BEST1 gene. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

Application Notes

Optimal dilution of the Bestrophin 1 antibody should be determined by the researcher.

Immunogen

Amino acids RFIYRLALTEEQQLMFEKLTLYCD were used as the immunogen for the Bestrophin 1 antibody.

Storage

After reconstitution, the Bestrophin 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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