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Home >> Antibodies >> Beclin 1 Antibody

Beclin 1 Antibody (R31504)

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Image R31504 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of Beclin 1 antibody and Lane 1: COLO320; 2: HepG2; 3: PANC; 4: A431; 5: SMMC-7721; 6: Jurkat; 7: SW620; 8: U87 lysate. Predicted molecular weight ~52 kDa.
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Western blot testing of Beclin 1 antibody and Lane 1: COLO320; 2: HepG2; 3: PANC; 4: A431; 5: SMMC-7721; 6: Jurkat; 7: SW620; 8: U87 lysate. Predicted molecular weight ~52 kDa.
IHC-P: Beclin 1 antibody testing of mouse spleen tissue
IHC-P testing of mouse intestine tissue
IHC-P testing of rat spleen tissue
IHC-P testing of rat intestine tissue
Flow cytometry testing of human HepG2 cells with Beclin 1 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Beclin 1 antibody.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Gene ID 8678
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Flow cytometry : 1-3ug/million cells
Limitations This Beclin 1 antibody is available for research use only.
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Description

Beclin 1, also known as also known as ATG6 or VPS30 is a protein that in humans is encoded by the BECN1 gene. Beclin 1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagosome in autophagy. This gene participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Schizophrenia is associated with low levels of the protein in the hippocampus of the affected which causes diminished autophagy which in turn results in increased neuronal cell death. It has been found that Beclin 1 can promote autophagy in autophagy-defective yeast with a targeted disruption of apg6/vps30, and in human MCF7 breast carcinoma cells.

Application Notes

Titration of the Beclin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Human partial recombinant protein (AA 1-354) was used as the immunogen for this Beclin 1 antibody.

Storage

After reconstitution, the Beclin 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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