BCA1 Antibody / B cell-attracting chemokine 1 / CXCL13 (R32484)

Description

BCA1 (B cell-attracting chemokine 1, CXCL13) is a CXC chemokine that binds CXCR5 to direct B cell trafficking and compartmentalization within lymphoid tissues. It shapes germinal center organization and supports positioning of T follicular helper cells, coordinating interactions required for antibody production and humoral immune architecture. BCA1 is produced by stromal and follicular dendritic cell populations and can be detected in secondary lymphoid organs and inducible lymphoid aggregates.

Through spatial guidance cues, BCA1 contributes to lymphoid tissue patterning, immune microenvironment maintenance, and adaptive response calibration. Its expression level and distribution serve as informative readouts in studies of lymphoid organogenesis, tertiary lymphoid structures, and cell–cell communication within stromal niches.

The BCA1 antibody enables specific detection of endogenous CXCL13 in applications such as immunohistochemistry, immunofluorescence, western blot of tissue or cell lysates, and ELISA for conditioned media or biological fluids. Researchers use the BCA1 antibody from NSJ Bioreagents to quantify protein abundance, map tissue localization, and evaluate pathway modulation under defined experimental conditions. With high specificity and consistent performance, the BCA1 antibody supports rigorous investigation of chemokine biology, lymphoid architecture, and immune signaling networks.

Application Notes

Optimal dilution of the BCA1 antibody should be determined by the researcher.

Immunogen

Amino acids I22-A109 were used as the immunogen for the BCA1 antibody.

Storage

Prior to reconstitution, store at 4oC. After reconstitution, the BCA1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.