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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Titration of the BAX antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This BAX antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 47-78 amino acids from the N-terminal region of human BAX.
Aliquot the BAX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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