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Home >> Antibodies >> BAX Antibody

BAX Antibody [clone 557CT5.2.1] (F40382)

  Catalog No Formulation Size Price (USD)  
Image F40382-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 379
Image
F40382-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 155
BAX antibody western blot analysis in MCF-7 lysate
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b
Clone Name 557CT5.2.1
Purity Purified
UniProt Q07812
Applications Western blot : 1:100
Limitations This BAX antibody is available for research use only.
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Description

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Application Notes

Titration of the BAX antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 28-56 from the human protein was used as the immunogen for this BAX antibody.

Storage

Aliquot the BAX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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