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Home >> Antibodies >> BAP1 Antibody / BRCA1-Associated Protein 1

BAP1 Antibody / BRCA1-Associated Protein 1 [clone BAP1/2432] (V7371)

  Catalog No Formulation Size Price (USD)  
Image V7371-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 429
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V7371-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 199
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V7371SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 429
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using BAP1 antibody (clone BAP1/2432). These results demonstrate the foremost specificity of the BAP1/2432 mAb.
Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
SDS-PAGE analysis of purified, BSA-free BAP1 antibody (clone BAP1/2432) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2c, kappa
Clone Name BAP1/2432
Purity Protein G affinity chromatography
UniProt Q92560
Localization Nuclear, cytoplasmic
Applications ELISA (order BSA/sodium azide-free format for coating) :
Limitations This BAP1 antibody is available for research use only.
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Description

The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.

Application Notes

Optimal dilution of the BAP1 antibody to be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Immunogen

A portion of amino acids 191-326 from the human protein was used as the immunogen for the BAP1 antibody.

Storage

Store the BAP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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