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Home >> Antibodies >> Bak Antibody

Bak Antibody (F42652)

  Catalog No Formulation Size Price (USD)  
Image F42652-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F42652-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
IHC analysis of FFPE hepatocarcinoma cancer tissue stained with the Bak antibody
Bak antibody western blot analysis in 1) Jurkat, 2) MDA-MB453 and 3) 293 lysate
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q16611
Applications IHC (Paraffin) : 1:50-1:100
Western blot : 1:1000
Limitations This Bak antibody is available for research use only.
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Description

BAK belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAK localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.

Application Notes

Titration of the Bak antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 56-91 from the human protein was used as the immunogen for this Bak antibody.

Storage

Aliquot the Bak antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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