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Home >> Antibodies >> BAG3 Antibody

BAG3 Antibody (R31212)

  Catalog No Formulation Size Price (USD)  
Image R31212 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of BAG3 antibody; Lane 1: MCF-7; 2: Jurkat; 3: A549; 4: HeLa; 5: COLO320 cell lysate. Predicted molecular weight ~62kDa but can be observed at 75~80kDa.
IHC-P: BAG3 antibody testing of human breast cancer tissue
IHC-P: BAG3 antibody testing of human intestine cancer tissue
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt O95817
Localization Cytoplasmic, some nuclear
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This BAG3 antibody is available for research use only.
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Description

BAG family molecular chaperone regulator 3 is a member of a conserved family of cyto-protective proteins that bind to and regulate Hsp70 family molecular chaperones. BAG3 mutations are responsible for familial dilated cardiomyopathy. Polymorphisms are also associated with sporadic forms of the disease together with HSPB7 locus. In muscle cells, BAG3 cooperates with the molecular chaperones Hsc70 and HspB8 to induce the degradation of mechanically damaged cytoskeleton components in lysosomes. This process is called chaperone-assisted selective autophagy (CASA) and is essential for maintaining muscle activity in flies, mice and men.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the BAG3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of human BAG family molecular chaperone regulator 3 (LEKLEQKAIDVPGQVQ) was used as the immunogen for this Bag3 antibody (100% homologous in human, mouse and rat).

Storage

After reconstitution, the BAG3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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